MORAb-004

MORAb-004

MORAb-004 is a IgG1 antibody that recognizes a cell surface protein, endosialin, also called Tumor Endothelial Marker-1 (TEM1) and CD248, which is expressed on a tumor associated pericytes and other tumor stromal cells. Pericytes are specialized cells that support the formation of blood vessels that support blood to tumors for their growth and survival. Expression of endosialin in tumors has been observed by several independent studies and experiments that block endosialin function have shown the ability to inhibit tumor growth and metastasis.

MORAb-004 is currently being developed as a therapeutic antibody for the treatment of many types of cancer. An Investigational New Drug (IND) application was opened for MORAb-004 in 2009. A Phase I study in patients with cancers is currently being conducted at Johns Hopkins. For more information click here.